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In term of design, both of these headphones are good for travel since both of them are full size foldable headphones, and in term of customer satisfaction, both receives great reviews from customers that these two headphones are match in term of quality, so what is the factor to define these two headphones ? The only factor to see which one is the best headphones for you is its sound character. Audio Technica headphones have been characterized as a great headphones for mid tone, with a wide sound stage, and best for a live music, while Sennheiser headphones have been characterized as a dark tone headphones, it means that it comes with a good mid tone for vocal, as well as deep bass, but some may feel that they lack of hi tone especially for hi tone details, or on the other hand, you may say that Audio Technica ATH-M50 has a brighter hi-tone than Sennheiser HD 280 Pro. (Sorry for my english).